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KMID : 1214920130190020123
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Soonchunhyang Medical Science
2013 Volume.19 No. 2 p.123 ~ p.127
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A Case of Favorable Responses after Gefitinib in a Patient with EGFR Mutated Adenosquamous Lung Carcinoma
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Cho Nam-Jun
Lee Ho-Sung
Jang Si-Hyong
Choi Jae-Sung
Na Ju-Ock
Seo Ki-Hyun
Kim Yong-Hoon
Kang Hyo-Chul
Kim Dae-Yeon
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Abstract
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In patients with advanced non-small cell lung cancer harboring epidermal growth factor receptor (EGFR) mutations, the epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are used as first treatment option. Because adenosquamous carcinoma (ASC) is a rare histologic subtype, evidences about EGFR-TKIs as first treatment option for advanced ASC are lacking. We report a case of an advanced ASC patient with the EGFR mutation, who showed good responses during 4-month treatment with gefitinib. And we will review about a necessity of EGFR mutation test and efficacy of EGFR-TKIs in ASC patients from the recent studies.
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KEYWORD
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Adenosquamous carcinoma, Epidermal growth factor receptor, Mutation, Non-small-cell lung carcinoma
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